Tecosactideke analogue ea maiketsetso ea 24-peptide corticotropin.Tatelano ea amino acid e ts'oana le li-amino acid tse 24 tsa amino-terminal ea corticotropin ea tlhaho (motho, bovine le porcine), 'me e na le ts'ebetso e ts'oanang ea 'mele joalo ka ACTH ea tlhaho."E tšoauoa ka ho ba sieo ha li-antibody, ka kakaretso ntle le litla-morao tse tebileng, 'me e loketse haholo-holo ho bakuli ba nang le ho kula kapa ba sa sebetseng ho porcine corticotropin ea tlhaho."
"E baka adrenal hyperplasia, e susumetsa tlhahiso ea lihomone tsa adrenocortical, haholo-holo (cortisol) le mineralocorticoids tse kang corticosterone, hape e susumetsa tlhahiso ea androgens, empa ka phello e fokolang."
Pampiri ena e hlalosa ka bokhutšoanyane ticcotide le litlamorao tsa eona tsa meriana
Ho ne ho e-na le phello e fokolang ho secretion ea aldosterone.Halofo ea bophelo ke lihora tse 3.Ka 2008, FDA e ile ea amohela Tecokotide ho tsoa ho Novartis bakeng sa tlhahlobo ea ho se sebetse hantle ha adrenal.Hajoale e ntse e ithutoa Univesithing ea Randboud bakeng sa kalafo ea idiopathic membranous nephropathy.
Mokhoa o felletseng oa motsoako oa mokelikeli ke mokhoa oa ho kopanya oa ticacotide.Mokhoa ona o na le mehato e mengata, nako e telele ea ho kopanya, 'me e hloka li-catalyst tse theko e boima le lisebelisoa tse phahameng tsa khatello, tse nang le mefokolo ea litšenyehelo tse phahameng, litšila tse ngata, kotsi ea ts'ebetso, le lihlahisoa tse tlaase.Ho 'nile ha tlalehoa hore ho kopanya ka bonngoe ho sebelisa leano la ts'ireletso ea Z, moo hydrogenation e sebelisetsoang ho tlosa setsi sa tšireletso mohatong o mong le o mong, o na le mehato e telele, ts'ebetso e boima, litšenyehelo tse phahameng le lihlahisoa tse tlaase.Serine e atisa ho ba le racemization ka lebaka la ho kopana ha motho a le mong nakong ea tlhoekiso, eo ho leng thata ho e hloekisa.
Joalo ka homone ea adrenocorticotropic, ticcotide e susumetsa tlhahiso ea lihomone tsa cortical (haholo-holo cortisol) ho tsoa adrenal cortex."Ka hona, ho ne ho se na phello ho bakuli ba nang le bothata bo matla ba adrenal cortical.
Ticocotide ke polypeptide ea maiketsetso e nang le li-amino acid tse 24.E tšoana ka sebopeho ho ea pele ho isa ho 24th amino acid ea ACTH.Tsamaiso ea methapo ka potlako e eketsa maemo a cortisol ea mali.Ho lokela ho sebelisoa ho rotha ka methapo e sa khaotseng ho boloka khatello ea mali ea cortisol.Bakeng sa ente ea intramuscular, serum cortisol e fihlile sehlohlolong sa eona ka 1h kamora ho entoa.Kamora moo, cortisol e phahameng e ka bolokoa lihora tse ka bang 24.
Nako ea poso: Jul-11-2023