Li-peptide tsena tsa antimicrobial qalong li ne li nkiloe litsamaisong tsa ts'ireletso ea likokoanyana, liphoofolo tse anyesang, tse phelang metsing, joalo-joalo, 'me li kenyelletsa mekhahlelo e mene:
1. cecropin qalong e ne e le teng ka lymph lymph ea 'mele ea Cecropiamoth, e fumanoang haholo likokoanyana tse ling, 'me li-peptide tse tšoanang tsa bactericidal li fumaneha hape ka maleng a likolobe.Ka tloaelo li khetholloa ke sebaka se matla sa alkaline sa N-terminal se lateloang ke sekhechana se selelele sa hydrophobic.
2. Xenopus antimicrobial peptides (magainin) e tsoa mesifa le mpa ea lihoho.Sebopeho sa lipeptide tsa xenopus antimicrobial le tsona li ile tsa fumanoa li le helical, haholo-holo libakeng tsa hydrophobic.Ho hlophisoa ha li-antipeptide tsa xenopus ka har'a lipid layers ho ile ha ithutoa ke N-lebelled solid-phase NMR.Ho ipapisitsoe le phetoho ea lik'hemik'hale ea acylamine resonance, li-helice tsa xenopus antipeptides e ne e le libaka tse bapileng tsa bilayer, 'me li ne li ka kopana ho etsa lesaka la 13mm le sebopeho sa helical sa nako le nako sa 30mm.
3. Defensin Defense peptides tsoa ho batho polykaryotic neutrophil rabbit polymacrophages le feletseng nyutlelie lobule le lisele tse mala a liphoofolo.Sehlopha sa li-peptide tse thibelang likokoana-hloko tse tšoanang le li-peptide tsa tšireletso ea mammalian li ile tsa ntšoa ho likokoanyana, tse bitsoang "li-peptide tse sireletsang likokoanyana".Ho fapana le li-peptide tsa tšireletso ea mammalian, li-peptide tsa ts'ireletso ea likokoanyana li sebetsa feela khahlano le libaktheria tsa Gram-positive.Esita le li-peptide tse sireletsang likokoanyana li na le masala a Cys a tšeletseng, empa mokhoa oa ho kopanya li-disulfide ho tse ling o fapane.Mokhoa o tlamang borokho oa intramolecular disulfide oa li-peptide tse thibelang likokoana-hloko tse nkiloeng ho Drosophila melanogast o ne o tšoana le oa li-peptide tse sireletsang limela.Tlas'a maemo a kristale, li-peptide tsa ts'ireletso li hlahisoa e le dimers.
4.Tachyplesin e tsoa ho makhala a pere, a bitsoang horseshoecrab.Lithuto tsa tlhophiso li bonts'a hore e amohela tlhophiso ea ho mena ha B-antiparallel (maemo a 3-8, maemo a 11-16), mooβ-angle e hokahane ho e mong (maemo a 8-11), 'me litlamo tse peli tsa disulfide li hlahisoa pakeng tsa maemo a 7 le a 12, le pakeng tsa maemo a 3 le a 16.Ka sebopeho sena, hydrophobic amino acid e fumaneha ka lehlakoreng le leng la sefofane, 'me masala a tšeletseng a cationic a hlaha mohatleng oa molek'hule, kahoo sebopeho se boetse se le biophilic.
Ho latela hore hoo e batlang e le li-peptide tsohle tsa antimicrobial li na le cationic ka tlhaho, le hoja li fapana ka bolelele le bolelele;Qetellong e phahameng, ebang ke ka mokhoa oa alpha-helical kapaβ- phutha, sebopeho sa bitropic ke tšobotsi e tloaelehileng.
Nako ea poso: Apr-20-2023