ACETYL-AMYLOID BETA/289634-54-4 /GT Peptide/Peptide Supplier

Tlhaloso

"Peptide ena ea cyclic e homologous ho domain e tlamang heparin ea APP e tlama ka matla ho heparin mme e thibela ho tlamaha ha 12 I-lebeled APP ho heparin (IC 50 = 10μM)."Peptide ena e thibetse APP-induced heparan sulfate proteoglycan-stimulation of neurite outroth.E bonahala e le phofo e tšoeu, peptide e entsoe ka lik'hemik'hale 'me e sebelisoa feela bakeng sa lipatlisiso tsa saense, eseng bakeng sa tšebeliso ea batho.Maemo a polokelo a ne a fapana ho tloha ho 80° C ho isa ho negative 20° C.

Litlhaloso

Ponahalo: Phofo e tšoeu ho isa ho e tšoeu

Bohloeki(HPLC):≥98.0%

Tšilafalo e le 'Ngoe:≤2.0%

Litaba tsa Acetate(HPLC): 5.0%～12.0%

Litaba tsa Metsi (Karl Fischer):≤10.0%

Litaba tsa Peptide:≥80.0%

Ho Paka le ho Romela: Mocheso o tlase, ho paka ka vacuum, ho nepahetse ho mg ha ho hlokahala.

Joang Ho Odara?

1. Contact us directly by phone or email: +86-13735575465, sales1@gotopbio.com.

2. Odara inthaneteng.Ka kopo, tlatsa foromo ea inthaneteng.

3. Fana ka lebitso la peptide, Nomoro ea CAS kapa tatelano, bohloeki le phetoho haeba ho hlokahala, bongata, joalo-joalo re tla fana ka khotheishene nakong ea lihora tse peli.

4. Khokahano ea taelo ka konteraka ea thekiso e saenneng ka nepo le NDA(tumellano ea ho se senole) kapa tumellano ea lekunutu.

5. Re tla tsoela pele ho ntlafatsa tsoelo-pele ea taelo ka nako.

6. Peptide e fana ka DHL, Fedex kapa ba bang, le HPLC, MS, COA e tla fanoa hammoho le thepa.

7. Leano la puseletso le tla lateloa haeba ho na le phapang ea boleng kapa tšebeletso ea rona.

8. Ts'ebeletso ea kamora thekiso: Haeba bareki ba rona ba na le lipotso mabapi le peptide ea rona nakong ea liteko, ka kopo ikutloe u lokolohile ho ikopanya le rona 'me re tla e araba ka nako e khutšoane.

Lihlahisoa tsohle tsa k'hamphani li sebelisoa feela molemong oa lipatlisiso tsa mahlale, eona'e thibetsoe ho sebelisoa ka kotloloho ke motho ofe kapa ofe 'meleng oa motho.

LBH:

Na li-peptide tse nang le Cys li ile tsa fokotsoa pele li romelloa?

Haeba peptide e sa fumanoe e na le oxidized, hangata ha re fokotse Cys.Li-polypeptide tsohle li fumanoa lihlahisoa tse sa hloekang tse hloekisitsoeng le tse lyophilized tlas'a maemo a pH2, ao bonyane ho isa bohōleng bo itseng a thibelang oxidation ea Cys.Li-peptide tse nang le Cys li hloekisoa ka pH2 ntle le haeba ho na le lebaka le itseng la ho hloekisa pH6.8.Haeba tlhoekiso e etsoa ka pH6.8, sehlahisoa se hloekisitsoeng se tlameha ho phekoloa ka asiti hang-hang ho thibela oxidation.Mohato oa ho qetela oa taolo ea boleng, bakeng sa li-peptide tse nang le Cys, haeba boteng ba boima ba molek'hule (2P + H) bo fumanoa 'mapeng oa MS, ho bontša hore dimer e thehiloe.Haeba ho se na bothata ka MS le HPLC, re tla lyophilize ka ho toba le ho romella thepa ntle le ts'ebetso e 'ngoe hape.Hoa lokela ho hlokomeloa hore li-peptide tse nang le Cys li kena butle ka oxidation ha nako e ntse e ea, 'me tekanyo ea oxidation e itšetlehile ka tatellano ea peptide le maemo a polokelo.

U ka tseba joang hore na peptide e na le looped?

Re sebelisa maikutlo a Ellman ho lekola hore na sebopeho sa reng se felile.Haeba tlhahlobo ea Ellman e le ntle (e mosehla), karabelo ea reng ha e ea fella.Haeba liphetho tsa liteko li le mpe (eseng mosehla), karabelo ea selikalikoe e felile.Ha re fane ka tlaleho ea tlhahlobo ea boitsebahatso ba cyclization bakeng sa bareki ba rona.Ka kakaretso, ho tla ba le tlhaloso ea liphetho tsa liteko tsa Ellman tlalehong ea QC.

Ke hloka cyclic peptide, e nang le tryptophan, na e tla ba oxidized?

Oxidation ea tryptophan ke ntho e tloaelehileng ho peptide oxidation, 'me hangata li-peptide li tsamaisoa ka baesekele pele li hloekisoa.Haeba oxidation ea tryptophan e etsahala, nako ea ho boloka peptide holim'a kholomo ea HPLC e tla fetoha, 'me oxidation e ka tlosoa ka tlhoekiso.Ho feta moo, li-peptide tse nang le oxidized le tsona li ka bonoa ke MS.

Na hoa hlokahala ho beha lekhalo lipakeng tsa peptide le dae?

Haeba u tla hokela molek'hule e kholo (joalo ka dae) ho peptide, ho molemo ho beha sebaka lipakeng tsa peptide le ligand ho fokotsa tšitiso ea moamoheli ka ho mena ha peptide ka boeona kapa ka ho mena ha conjugate ea eona.Ba bang ha ba batle linako.Ka mohlala, ha ho mena liprotheine, hoa khoneha ho fumana hore na sebopeho sa amino acid se arohane hakae ka ho hokela dae ea fluorescent sebakeng se itseng.

Haeba u batla ho etsa phetoho ea biotin setsing sa N, na u hloka ho beha lekhalo lipakeng tsa biotin le tatelano ea peptide?

Mokhoa o tloaelehileng oa ho ngola li-biotin o sebelisoang ke k'hamphani ea rona ke ho hokela Ahx ho ketane ea peptide, e lateloe ke biotin.Ahx ke motsoako oa 6-carbon o sebetsang e le mokoallo pakeng tsa peptide le biotin.

A na u ka fana ka likeletso mabapi le moralo oa li-peptide tsa phosphorylated?

Ha bolelele bo ntse bo eketseha, katleho e tlamang e fokotseha butle-butle ho tloha ho phosphorylated amino acid ho ea pele.Tataiso ea ho kopanya e tsoa ho terminal ea C ho ea ho N terminal.Ho khothalletsoa hore mesaletsa ka mor'a phosphorylated amino acid e se ke ea feta 10, ke hore, palo ea masala a amino acid pele ho phosphorylated amino acid ho tloha N terminal ho ea C terminal ha ea lokela ho feta 10.

Hobaneng ha n-terminal acetylation le C-terminal amidation?

Liphetoho tsena li thibela peptide ho senyeha le ho lumella peptide ho etsisa boemo ba eona ba pele ba lihlopha tsa alpha amino le carboxyl protheine ea motsoali.