conotoxin (conopeptide, kapa CTX), sejo sa li-peptide tse ngata tse monotoxic tse hlahisoang ke li-tubes tsa chefo le litšoelesa tsa Marine gastropod invertebrate Conus (Conus).Likarolo tse kholo ke lik'hemik'hale tse sebetsang tsa polypeptide tse ikhethileng haholo ho likanale tse ling tse fapaneng tsa calcium le li-receptor tsa tsamaiso ea methapo.Chefo ea khofu ka 'ngoe e na le li-peptide tse sebetsang tse 50 ho isa ho tse 200.Mefuta e fapaneng ea likhofu tsa conic e na le li-peptide tse sebetsang tse fapaneng, le haeba likhofu tse tšoanang ka lebaka la libaka tse fapaneng, likarolo tsa tsona tsa chefo li ka fapana, ha e le hantle ho ka ba le li-peptide tse sebetsang tse fetang likete tse 50 tse chefong ea likhofu.Conotoxin hangata e entsoe ka masala a 10 ~ 40, a nang le lihlopha tse peli kapa tse tharo tsa bond ea disulfide, e fumanoa e le palo e nyane ka ho fetisisa ea nucleic acid ea biological neurotoxic peptide, hape ke bongata bo boholo ba peptide e nyane ea disulfide, e ka sebelisoa ho mefuta eohle. ea likanale tsa calcium le mefuta ea li-receptor le subtypes.
Litlamorao tsa conotoxin letlalong le sosobaneng ke tse latelang:
Conotoxin, ke lelapa la conotoxin, ke mofuta oa litlamorao tse ling tse thibelang botsofali tsa lehlakore, hobane e ka fokotsa botebo ba mela e metle ea letlalo, ea imolla ho tiea ha letlalo, ea fetoha leseli le elastic, ea fifala mela e metle, ebe e fumana motho e mong le e mong. thatohatsi.E bitsoa "Naleli e khahlanong le botsofali."
Conotoxin e ka thibela tlhahiso ea mela e metle ea sefahleho, ea ntlafatsa ho khatholoha ha letlalo, ea ntlafatsa letlalo la elasticity, ea ntlafatsa boleng ba letlalo le botebo ba mela e metle.E thusa ho fokotsa ho ruruha ha letlalo, ho lumella letlalo hore le lokise ho tsitsisa ha lona le ho ntlafatsa boleng ba letlalo.
Conotoxin e fetohile e 'ngoe ea mekhoa e sebelisoang ka ho fetisisa ea ho thibela botsofali ka lebaka la ts'ebetso ea eona e babatsehang ea ho thibela botsofali.Ka mekhoa e khethehileng, conotoxin e ka kenngoa letlalong la sefahleho ho ntlafatsa elasticity ea eona.
Conotoxin e le mofuta o thibelang botsofali, o na le phello e matla ea ho thibela botsofali, kahoo e ka rua molemo haholo ho ntlafatsa boemo ba letlalo, ho tlosa makukuno, ho etsa hore letlalo le shebahale le le lecha le letle haholoanyane.
Nako ea poso: May-09-2023