selelekela
Gorelatide, e tsejoang hape e le n-acetyl-serine – aspartic acid – proline – proline -(N-Acetyl-Ser-Asp-Ls-Pro), khutsufatsoa e le Ac-SDKP, ke endogenous tetrapeptide, nitrogen end acetylation, e ajoang haholo dinama tse fapaneng le maro a mmele a mmele.Tetrapeptide ena e lokolloa ke prolyl oligopeptidase (POP), e bakoang haholo ke selelekela sa eona sa thymosin.Khatello e maling hangata e ba sekala sa nanomole.
okinetics
Ho ea ka thuto ea pharmacokinetic ea Gorelatide, ka mor'a ente ea methapo, Gorelatide e senyeha ka potlako ka halofo ea bophelo ea 4 ~ 5min feela.Gorelatide e hlakoloa ho plasma ea motho ka mekhoa e 'meli:①Angiotensin-converting enzyme (ACE) - tataiso ea hydrolysis;②Ho sefa ha glomerular.Hydrolysis ea angiotensin converting enzyme (ACE) ke tsela e ka sehloohong ea metabolism ea gorelatide.
Mosebetsi oa likokoana-hloko
Gorelatide ke mofuta oa taolo ea fisioloji e sebetsang ka bongata e nang le mesebetsi e fapaneng ea tlhaho.Ho ile ha tlalehoa pejana hore Gorelatide e ka thibela ho kena ha lisele tsa stem tsa pele tsa hematopoietic karolong ea S le ho etsa hore li eme karolong ea G0, ho thibela mosebetsi oa lisele tsa stem tsa hematopoietic.Ka mor'a moo ho ile ha fumanoa hore Gorelatide e ka ntlafatsa bokhoni ba ho tsosolosa epidermal ka ho khothalletsa ho thehoa ha methapo ea mali le ho potlakisa pholiso ea maqeba ho li-grafts tse senyehileng tsa vascularized epidermal.Gorelatide e ka thibela ho arohana ha lisele tsa 'mele oa masapo tse hlohlellelitsoeng ke MGM ho li-macrophages, kahoo li bapala karolo e khahlanong le ho ruruha.Gorelatide e sa tsoa fumanoa e thibela ho ata ha lisele tse sa tšoaneng.
tshebediso
Joalo ka polypeptide organic matter, Gorelatide e ka sebelisoa e le thepa e tala ea lithethefatsi.
Nako ea poso: Apr-26-2023