Kakaretso le tšebeliso ea cerulein

Kakaretso

Caerulein, eo hape e tsejoang e le cerulein, ke karolo ea letlalo la senqanqane sa Australia HYlacaerulea se nang le li-amino acid tse 10.Ke molek'hule ea decapeptide e fanoang ke trifluoroacetate e sebetsang e le analogue ea cholecystokinin liseleng tsa pancreatic vesicular mme e ka lebisa ho secretion ea palo e kholo ea li-enzyme tsa tšilo le lero la pancreatic, e bakang pancreatitis e hlobaetsang.Cerutin e ka sebelisoa ho ithuta liprotheine tsa Nf-κb up-regulation tse kang intercellular adhesion molecule-1 (ICAM-1) lintlha tse amanang le ho ruruha tse kang NADPH oxidase le Janus kinase mediated signal transduction.E sebelisitsoe ka katleho ho theha mefuta ea pancreatitis e matla ho likhoto, litoeba, lintja le li-hamster tsa Syria (AP).Mekelikeli e kenang methapong e sebelisoa hamolemo ka ho sebelisa ente e kenang methapong, ea dermal kapa ea intraperitoneal.E sebelisoa haholo litekong tsa bongaka tsa acute edematous pancreatitis, 'me liteko tsa in vitro li sebelisoa mefuteng ea lisele.Ho feta moo, e sebelisoa ho hlahloba mosebetsi oa gallbladder.

Kakaretso le tšebeliso ea cerulein

Lintlha tse qaqileng

Ponahalo: phofo e tšoeu

Nomoro ea CAS: 17650-98-5

Nomoro ea Gutuo: GT-F055

Tatelano: pGlu-Gln-Asp-Tyr(SO3H)-Thr-Gly-Trp-Met-Asp-Phe-NH2

Mokhoa oa molek'hule: C58H73N13O21S2

Boima ba molek'hule: 1352.4

Sollubility: E qhibilihisoa ka 50mM ammonium hydroxide ka bongata ba 1.0mg/ml

Kopo

1. E sebelisoa haholo ho etsa mohlala oa acute edematous pancreatitis litekong tsa bongaka.

2. Kopo ho mefuta ea lisele tsa vitro.

3. E sebelisetsoa tlhahlobo ea mosebetsi oa gallbladder.

Ho theha mohlala bakeng sa thuto ea pancreatitis e hlobaetsang bakeng sa thuto ea cerulein (AP) cell biology, litšobotsi tsa pathophysiological le lipontšo tsa mafu a organic ho pancreatitis e hlobaetsang.Ntle le ho batlisisa liphetoho tsa pulmonary tsa lefu la AP, e ka boela ea bontša ka katleho ho sebelisana ha visceral endocrine joalo ka boemo ba metabolin le CCK.E ka boela ea sebelisoa ho hlahloba tsosoloso le ho hlaphoheloa ha lisele tse lemetseng ka mor'a ho felisoa ha lintho tse kotsi.

5. Tšebeliso ea Caerulein cerulein (cerulein) le LPS ho theha mehlala ea pancreatitis e ka hlahisa liphello tsa synergistic, ea pele e ka susumetsa li-enzyme tsa pancreatic ho senya manyeme, le ho tsoela pele ho kenya lisele tsa ho ruruha hore li lokolle mabaka a ho ruruha.Ka mor'a moo, LPS e sitisa karabelo e tloaelehileng ea bakena-lipakeng ba ho ruruha, ka hona ho hlahisa pancreatitis e le mokhoa o matla oa ho ruruha.

6. Cerulein e ka sebelisoa ho thibela bohloko ba gallbladder, renal colic, le bohloko ba nakoana ba claudication.Ka kakaretso e nkuoa e le mohanyetsi ea sa feleng kephalin.