Mokhoa oa ts'ebetso
Li-enzyme ke liprotheine tse susumetsang karabelo ea lik'hemik'hale.Enzyme e sebelisana le substrate ho e fetola sehlahisoa sa ho qetela.Li-inhibitors li tlamellana ho thibela substrate ho kena sebakeng se sebetsang sa enzyme le / kapa ho thibela enzyme ho susumetsa karabelo.Ho na le mefuta e mengata ea li-inhibitors tse kenyelletsang: tse sa tobang, tse ke keng tsa fetoloa, tse ka khutlisetsoang morao - tse nang le tlhōlisano le tse se nang tlhōlisano.Li-reversible inhibitors li tlama ho li-enzyme tse nang le litšebelisano tse sa kopaneng (mohlala, litšebelisano tsa hydrophobic, hydrogen le ionic bond).Mehato e sa lebelloang ea taolo e kenyelletsa hore qetellong e hlahisoe karolo ea protheine ea enzyme, ka hona, ho qoba liphetoho tsohle tsa 'mele kapa tsa lik'hemik'hale.Li-inhibitor tse khethehileng li sebetsa ho enzyme e le 'ngoe.Bongata ba chefo bo sebetsa ho latela li-enzyme tse itseng tsa taolo.Competitive inhibitors ke metsoako kaofela e ts'oanang hantle le sebopeho sa lik'hemik'hale le geometry ea molek'hule ea substrate ea reaction.Inhibitor e ka sebelisana le enzyme sebakeng se sebetsang, empa ha ho na karabelo e hlahang.Noncopetitive inhibitors ke lintho tse sebelisanang le li-enzyme empa hangata ha li sebelisane sebakeng se sebetsang.Sepheo sa marang-rang sa inhibitor e se nang tlhōlisano ke ho fetola sebōpeho sa enzyme, kahoo e ama sebaka se sebetsang, e le hore substrate e se e sa khone ho sebelisana le enzyme ho itšoara.Li-non-competitive inhibitors hangata li ka khutlisetsoa morao.Irreversible inhibitors e theha maqhama a matla a covalent le li-enzyme.Tse ling tsa li-inhibitors tsena li ka sebetsa sebakeng kapa haufi le sebaka se sebetsang.
tshebediso
Li-Enzyme li sebelisoa haholo khoebong libakeng tsa indasteri, joalo ka ho hlatsoa lijana, lijo le liindasteri tsa ho ritela.Li-protease li sebelisoa ka "microbial" ho hlatsoa phofo ho potlakisa ho senyeha ha liprotheine tse litšila tse kang mali le mahe.Tšebeliso ea khoebo ea li-enzyme e kenyelletsa hore li qhibiliha metsing, e leng se etsang hore ho be thata ho li sebelisa hape, le hore lihlahisoa tse ling li thibela tšebetso ea enzyme (taolo ea maikutlo).
Limolek'hule tsa lithethefatsi, limolek'hule tse ngata tsa lithethefatsi ha e le hantle ke li-enzyme inhibitors, 'me li-inhibitors tsa enzyme hangata li khetholloa ka ho khetheha le phello ea tsona.Boemo bo phahameng le phello e bontšitse hore lithethefatsi li na le maikutlo a fokolang a fokolang le chefo e batlang e le tlaase.Li-enzyme inhibitors li fumaneha tlhahong 'me li reriloe le ho hlahisoa e le karolo e nyane ea pharmacology le biochemistry 6.
Chefo ea tlhaho hangata ke li-enzyme inhibitors tse bileng teng ho sireletsa lifate kapa liphoofolo tse fapaneng ho libatana.Chefo ena ea tlhaho e kenyelletsa metsoako e mengata e chefo e kileng ea sibolloa.
Nako ea poso: Apr-25-2023