L-carnosine ke molek'hule e nyane e nang le sebopeho sa "dipeptide" sa tlhaho se bōpehileng joaloka L seo hangata se fumanoang tlhahong 'me se entsoe ka libopeho tsa tlhaho tsa dipeptide tse bōpehileng joaloka L tse atisang ho fumanoa tlhahong.Peptide e entsoeng ka β-alanine le L-histidine.Carnosine e na le mefuta e fapaneng ea li-antioxidant tsa cellular, anti-botsofali le mesebetsi ea tlhokomelo ea bophelo bo botle ba 'mele le litlamorao tsa bongaka, joalo ka khatello ea mali, lefu la pelo, senile cataract, ho hlaphoheloa ha seso, anti-tumor, tlhahlobo ea mohlala oa ho itšireletsa mafung, lintlha tse khahlanong le khatello ea maikutlo joalo-joalo.
Karolo ea
Carnosine ke carnosine e fumanoang ke rasaense oa Russia Gulevich hammoho le carnitine.United Kingdom, Korea, Russia le Chaena tse ling, liphuputso li bontšitse hore carnosine e na le matla a matla a antioxidant 'me e molemo ho batho.Carnosine e bontšitsoe hore e tlosa mefuta e mengata ea oksijene (ROS) e entsoeng ke oxidation e feteletseng ea mafura a mafura ka har'a membrane ea sele nakong ea khatello ea kelello ea oxidative, hammoho le α-β unsaturated aldehydes.
Liphuputso tse ngata li fumane hore N-acetylcarnosine e na le phello e ntle ho thibela le ho phekola lefu la cataract.E 'ngoe ea liphuputso tsena e bontšitse hore carnosine e ntlafalitse cataract e bakoang ke crystalline opacities ho likhoto tse bakoang ke ho pepesehela guanidine.Le hoja lipolelo tsena li tšehetsa melemo e mengata ea ho inahanela leihlo e kang phekolo ea carnotin bakeng sa lera la mahlo, ho fihlela joale, ha e e-s'o tšehetsoe ka botlalo ke sechaba sa bongaka se tloaelehileng.Ka mohlala, Royal Orthopedics e ne e boletse hore carnosine e ne e sa sireletseha ebile e sa sebetsa hantle kalafong ea lera la mahlo.
Ho ea ka tlaleho ea 2002, carnosine e ka ntlafatsa likamano tsa sechaba le ho eketsa mantsoe a sebelisoang ke bana ba nang le autism, empa lintlafatso tse boleloang thutong li ka boela tsa tsoa ho ntlafatso, placebo, kapa lintlha tse ling tse sa ngoloang phuputsong ena.
Mokhoa oa ho kopanya
Hona joale, mekhoa ea tlhahiso ea carnosine e na le mefokolo e meng e tloaelehileng: ka lebaka la ho fokotseha ha karabelo ea lehlakore, karabelo ena e lehlakoreng e etsoa ka ho kenya letsoho ha lesale la L-histidine imidazole.L-histidine e tla potoloha bonyane 0.8% ts'ebetsong ea ho itšoara, ho fokotsa lihlahisoa tsa sehlahisoa;Ka nako e ts'oanang, ho thata ho arola L-carnosine ka bohloeki bo botle bo hloekileng ba optical ho tsoa ho metsoako e kotsi (mokhoa oa eona oa ho potoloha, isomers ea imidazole, joalo-joalo), e amang bohloeki ba khoebo, hobane metsoako ena e na le thepa e tšoanang ea physicochemical ho L-carnosine.Ka lebaka la ho ba teng ha metsoako ena, L-carnosine e hlahisoang e na le chefo, ho e-na le ho itokisa pele ho hloekileng.
Mokhoa o mocha oa tlhahiso ea L-carnosine ke o latelang: phthalic anhydride e arabela β-alanine ka phthalic anhydride β-phthaloylalanine, chlorinated reagent chlorides phthaloyl-β-phthaloylalanine ho phthaloyl-alanine β-alanyl chloride;L-trialkylsilane e sireletsang motsoako o sebetsana le trialkylchlorosilane kapa hexahydroxysilane, e sebetsana le phthalyl β-alanyl chloride condensation ea hydrochloride, e tlosa sehlopha se sireletsang ka joala ea anhydrous, le synthetates hydrochloride ka alkaline tharollo ho fumana intermediate hydrochlorazites hydrochlorazite product synthesis L-carnosine ka joala bo se nang metsi.Sehlahisoa sena ke lesale la imidazole ho histidine e sirelelitsoeng ho L ho qoba litla-morao tsa lesale la imidazole ho L-histidine le lintho tse ling, 'me u fumane L-carnosine e hloekileng e nang le litla-morao tse fokolang le lihlahisoa tse ngata tse phahameng.
Nako ea poso: Oct-24-2023