Na trifluoroacetyl tripeptide-2 e ka lieha ho tsofala?

Mabapi le rona:

Peptide ke letoto la li-amino acid tse hokahaneng le li-bond tsa peptide.Li-peptide li ameha haholo taolong ea liprotheine, angiogenesis, ho ata ha lisele, melanogenesis, ho falla ha lisele le ho ruruha.Li-peptide tsa bioactive li 'nile tsa sebelisoa haholo indastering ea litlolo lilemong tse mashome tsa morao tjena.Li-peptide li hloka boima bo tlase ba limolek'hule (> 500 Da), e le ho fokotsa ho ata ha peptide pakeng tsa likarolo tsa epidermal, botsitso bo phahameng le ho qhibiliha.Ho theosa le lilemo, sechaba sa mahlale se thehile sekhechana se senyenyane le se tsitsitseng sa peptide ea maiketsetso se kenyang tlhahiso ea collagen le ho fokotsa matsuba a sefahleho le mebala.Trifluoroacetyl tripeptide-2 (sequence: TFA-Val-Try-Val-OH) tripeptide synthesis, e entsoeng e le matrix metalloproteinase le elastase inhibitor.Lithuto tsa in vitro mabapi le ts'ireletso ea ECM ka trifluoro-acetyl tripeptide 2(TT2), motsoako oa proteoglycan litšebelisanong tsa cell-matrix, le phello ea progerin synthesis ho fibroblasts e tloaelehileng ea batho e sa tsoa tsejoa e le motsoako oa li-cellular. senescence.Liphetho li fana ka maikutlo a hore trifluoroacetyl tripeptide 2 e na le mefuta e pharalletseng ea thepa e thibelang botsofali.Sena se fokotsa tlhahiso ea progerin, se eketsa tlhahiso ea proteoglycan, 'me se honyela collagen, kahoo se fokotsa masoba le ho ntlafatsa ho tiea ha lisele.Ntle le moo, litlamorao tsa eona tse khahlanong le wrinkling, anti-phallo le litlamorao tse tiisang letlalo li ile tsa hlahlojoa lithutong tse peli tsa sefahleho tse arohaneng tsa in vitro.Trifluoroacetyl tripeptide 2 e bonts'itsoe hore e na le litlamorao tse tsoelang pele ho wrinkles, tightness, elasticity le sagging.

Na trifluoroacetyl tripeptide-2 e ka lieha ho tsofala?

Liphuputso li bontšitse hore senescence ea sele e amana haufi-ufi le Progerin.Ka botsofali, presenilin e bokellana le ho feta 'meleng, e lebisang ho bofokoli ba nyutlelie le tšenyo ea DNA, e lebisang botsofaling ba letlalo.Trifluoroacetyl tripeptide-2 ke tripeptide e sebetsang ea Elafin, e tsoang ho elastase inhibitor.E fokotsa tlhahiso ea Progerin 'me e ntlafatsa ho ba le letlalo laxity, ho sisinyeha le wrinkles.

Mokhoa

1. Thibela motsoako oa Progerin ho liehisa senescence ea cellular.

2. Khothaletsa tlhahiso ea li-syndecan le ho lelefatsa bophelo ba lisele.

3. Thibela mosebetsi oa matrix metalloproteinases MMP1, MMP3 le MMP9, fokotsa ho senyeha ha liprotheine tsa matrix tsa extracellular le ho boloka botšepehi ba tsona.

4. Thibela mosebetsi oa elastase, fokotsa ho senyeha ha elastin, 'me u etse hore letlalo le be thata le ho feta.

Kopo

E loketse mefuta eohle ea li-anti-wrinkle le tse khahlanong le botsofali, ho lokisa ho tiisa, ho thibela photoaging, tlhokomelo ea 'mele ka mor'a ho beleha le ka mor'a letsatsi, joalo-joalo E eketsoa karolong ea ho qetela ea tlhahiso ea litlolo.