Penicillin e bile sethibela-mafu sa pele lefatšeng se sebelisoang litsing tsa bongaka.Ka mor’a lilemo tsa tsoelo-pele, lithibela-mafu tse ntseng li eketseha li ile tsa hlaha, empa bothata ba ho hanyetsa lithethefatsi bo bakoang ke ho ata ha lithibela-mafu bo ’nile ba bonahala butle-butle.
Li-peptide tsa antimicrobial li nkuoa li na le tebello e pharaletseng ea ts'ebeliso ka lebaka la ts'ebetso ea tsona e phahameng ea antibacterial, mefuta e mengata ea li-antibacterial spectrum, mefuta e fapaneng, mefuta e mengata ea khetho, le liphetoho tse fokolang tsa ho hanyetsa mefuteng ea sepheo.Hajoale, li-peptide tse ngata tsa antimicrobial li mothating oa lipatlisiso tsa bongaka, tseo har'a tsona li-mainins(Xenopus laevis antimicrobial peptide) li keneng tekong ea Ⅲ ea bongaka.
Mekhoa e sebetsang hantle e hlalositsoeng
Li-peptide tse thibelang likokoana-hloko (amps) ke li-polypeptide tsa motheo tse boima ba molek'hule ea 20000 'me li na le tšebetso ea antibacterial.Pakeng tsa ~ 7000 mme e entsoe ka masala a amino acid a 20 ho isa ho 60.Boholo ba li-peptide tsena tse sebetsang li na le litšobotsi tsa motheo o matla, botsitso ba mocheso, le antibacterial e pharaletseng.
Ho ipapisitsoe le sebopeho sa bona, li-peptide tsa antimicrobial li ka aroloa ka mekhahlelo e mene: helical, sheet, extended, le ring.Li-peptide tse ling tsa antimicrobial li na le helix e le 'ngoe feela kapa lakane, ha tse ling li na le sebopeho se rarahaneng.
Mokhoa o tloaelehileng oa ts'ebetso ea li-peptide tse thibelang likokoana-hloko ke hore li na le ts'ebetso e tobileng khahlanong le lera la lisele tsa baktheria.Ka bokhutšoanyane, li-peptide tse thibelang likokoana-hloko li senya bokhoni ba lera la baktheria, li fetola ho phunyeha ha lera, li-metabolite tse lutlang, 'me qetellong li lebisa lefung la baktheria.Sebopeho se qosoang sa li-peptide tse thibelang likokoana-hloko li thusa ho ntlafatsa bokhoni ba tsona ba ho sebelisana le lisele tsa baktheria.Bongata ba li-peptide tse thibelang likokoana-hloko li na le tefiso e ntle, kahoo li bitsoa cationic antimicrobial peptides.Tšebelisano ea electrostatic pakeng tsa cationic antimicrobial peptides le anionic bacterial membranes e tsitsisa ho tlama ha li-peptide tse thibelang likokoana-hloko ho lera la baktheria.
Bokhoni ba ho phekola bo hlahang
Bokhoni ba li-peptide tsa antimicrobial ho sebetsa ka mekhoa e mengata le likanale tse fapaneng ha li eketse ts'ebetso ea antimicrobial feela empa hape li fokotsa tšekamelo ea ho hanyetsa.Ho sebetsa ka likanale tse ngata, monyetla oa hore libaktheria li fumane liphetoho tse ngata ka nako e le 'ngoe li ka fokotsoa haholo, tsa fa li-peptide tsa antimicrobial matla a ho hanyetsa.Ho feta moo, hobane li-peptide tse ngata tsa antimicrobial li sebetsa libakeng tsa lera la baktheria, libaktheria li tlameha ho hlophisa bocha sebopeho sa lera la sele hore li fetohe, 'me ho nka nako e telele hore liphetoho tse ngata li etsahale.Ho tloaelehile haholo ho chemotherapy ea mofetše ho fokotsa ho hanyetsa hlahala le ho hanyetsa lithethefatsi ka ho sebelisa mekhoa e mengata le mahlahana a fapaneng.
Tebello ea kliniki e ntle
Theha litlhare tse ncha tsa antimicrobial ho qoba koluoa e latelang ea likokoana-hloko.Palo e kholo ea li-peptide tse thibelang likokoana-hloko li ntse li lekoa 'me li bontša bokhoni ba bongaka.Mosebetsi o mongata o sa ntse o lokela ho etsoa ka li-peptide tse thibelang likokoana-hloko e le li-antimicrobial agents tse ncha.Li-peptide tse ngata tsa antimicrobial litekong tsa bongaka li ke ke tsa tlisoa 'marakeng ka lebaka la moralo o fosahetseng oa liteko kapa ho hloka bonnete.Ka hona, lipatlisiso tse ling mabapi le tšebelisano ea li-antimicrobial tse thehiloeng ho peptide le tikoloho e rarahaneng ea batho li tla ba molemo ho lekola bokhoni ba 'nete ba lithethefatsi tsena.
Ehlile, metsoako e mengata litekong tsa bongaka e bile le phetoho e itseng ea lik'hemik'hale ho ntlafatsa thepa ea eona ea bongaka.Ts'ebetsong, ts'ebeliso e matla ea lilaeborari tse tsoetseng pele tsa dijithale le nts'etsopele ea software ea mohlala e tla ntlafatsa le ho ntlafatsa lipatlisiso le nts'etsopele ea lithethefatsi tsena.
Le hoja moralo le nts'etsopele ea li-peptide tse thibelang likokoana-hloko e le mosebetsi o nang le moelelo, re tlameha ho leka ka matla ho fokotsa khanyetso ea li-antimicrobial agents tse ncha.Nts'etsopele e tsoelang pele ea li-antimicrobial agents le mekhoa e thibelang likokoana-hloko e tla thusa ho fokotsa tšusumetso ea lithibela-mafu.Ntle le moo, ha ho behiloe moemeli e mocha oa antibacterial 'marakeng, ho hlokahala tlhahlobo e felletseng le taolo ho fokotsa ts'ebeliso e sa hlokahaleng ea li-antibacterial ka hohle kamoo ho ka khonehang.
Nako ea poso: Jul-04-2023