Peptide e tloaelehilengSynthesisTshebeletso
Hangzhou Go Top Peptide Biotech , e thehiloeng ka 2014, ke a Kgwebo ya Naha ya Theknoloji e Phahamenge sebetsanang le lipatlisiso, nts'etsopele le tlhahiso ea li-peptide le tse ling tse amanang le tsona.
Ea k'hamphanisetsi sa lipatlisiso tsa peptidehajoale e fumaneha Seterekeng sa Qiantangof Hangzhou, e koahelang sebaka sa lisekoere-mithara tse fetang 3,000.Thekhampani's fektheri e fumaneha No.24, Haitian Road, Setereke sa Shangyu, motseng oa Shaoxing, profinseng ea Zhejiang.Ho boetse ho na le limela tse peli tsa tšebelisano, e 'ngoe ke eatlhahiso ea peptide ea khoebo ea GMP teng kaAnji seterekeng sa profinse ea Zhejiang, e 'ngoe ke ea API e nyane ea molek'hule e tengYuncheng e profinseng ea Shanxi.Re fetohakhoebo e akaretsang ea theknoloji e phahameng, ho kopanya lipatlisiso, tekanyo ea lifofane, khoebo le thekiso ea lefatše lohle.
Khampani e na lefedile100basebetsi,mme e na lentshetswa pele hofeta40 e holileng merianali-peptide,ho fetaLi-patent tse 10 tsa boqapili fuoe tumello.Tmatla a tlhahiso ea selemo le selemois ho fihlela100 lik'hilograma, palo ea li-peptide tse tloaelehileng li na le e fihlile ka holimo ho 20,000.Re ka fana ka lits'ebeletso tsa sebaka se le seng sa peptide ho tloha lipatlisisong(mg) ho isa khoebong (KGs).
Lethathamo la Phetoho ea Peptide
N-terminal liphetoho
| {N-Me-Ala} | {N-Me-Asp} | {N-Me-Glu} | {N-Me-Ile} |
| {N-Me-Leu} | {N-Me-Met} | {N-Me-Nle} | {N-Me-Nva} |
| {N-Me-Phe} | {N-Me-Ser} | {N-Me-Thr} | {N-Me-Tyr} |
| {N-Me-Val} | {Sar} | N-Me-Arg | N-Me-Asn |
| N-Me-beta-Ala | N-Me-Gln | N-Me-Lys | N-Me-Trp |
C-terminal liphetoho
| {Borokho ba Mono Disulfide} | {Double Disulfide Bridge} | {Borokho ba Triple Disulfide} |
| {Random Disulfide borokho} | {Sekhechana se tšoanang.Borokho ba Inter-Disulfide } | {Borokho bo fapaneng ba Inter-Disulfide} |
| {Amide cyclic (qetellong)} | {Amide cyclic (Side chain)} | {Orn side chain Amide cyclic} |
| {Thioester cyclic} | {lactone cyclic} | {Sec cyclic} |
Li-amino acid tse sa tloaelehang
| {2-Aze} | {3-Aze} | {5,5-Dime-Pro} |
| {5-ASA} | {Abu} | {Ac-Ls} |
| {Ebe} | {Beta-Asp} | {Bpa} |
| {Cha} | {Chg} | {Cit} |
| {Cpg} | {Cys(Acm)} | {Cys(Bzl)} |
Isotope e ngotsoeng ka li-peptide
| Lys(13C6,15N2) | Ile(13C6,15N) |
| Leu(13C6,15N) | Val(13C5, 15N) |
| Arg(13C6, 15N4) |
Liphetoho tsa peptide ea fluorescent / lipara tsa FRET
| Biotin - | Dansyl- | Peptide ea fluorecent e tima |
| Biotin-Ahx- | Dansyl-Ahx- | Dabcyl |
| 5-FAM- | Cy3- | Dabcyl / Glu(Edans)-NH2 |
| 5-FAM-Ahx- | Cy5- | Dansyl- |
| FITC- | MCA/DNP | Dansyl-Ahx- |
| FITC-Ahx- | AMC | Edans / Dabcyl |
Peptide Conjugates
| BSA(-COOH ea C terminal | KLH(-NH2 ea N terminal) | OVA(-COOH ea C terminal) |
| Khokahano ea BSA ho Cys | Khokahano ea KLH ho Cys | OVA(-NH2 ea N terminal) |
| Kopano ea OVA ho Cys |
Phosphorylation
| {pSer} | {D-pSer} |
| {pTyr} | {D-pTyr} |
| {pThr} | {D-pThr} |
Liphetoho tse ling (PEGylation, Cyclic modifications, Disulfide Bridges)
| PEGylation | Liphetoho tsa cyclic | Marokho a Disulfide |
| {Mini-PEG1} | Head to tail cyclic | {Borokho ba Mono Disulfide} |
| {Mini-PEG2} | {Double Disulfide Bridge} | |
| {PEG-11} | {Borokho ba Triple Disulfide} | |
| {PEG-12} | {Random Disulfide borokho} | |
| …… | …… | …… |